Much contemporary Catholic missionary work has undergone profound change since the Second Vatican Council, and has become explicitly conscious of Social Justice issues and the dangers of cultural imperialism or economic exploitation disguised as religious conversion. Contemporary Christian missionaries argue that working for justice is a constitutive part of preaching the Gospel, and observe the principles ofinculturation in their missionary work.

As the church normally organizes itself along territorial lines, and because they had the human and material resources, religious orders—some even specializing in it—undertook most missionary work, especially in the early phases. Over time a normalised church structure was gradually established in the mission area, often starting with special jurisdictions known as apostolic prefectures and apostolic vicariates. These developing churches eventually intended 'graduating' to regular diocesan status with a local episcopacy appointed, especially after decolonization, as the church structures often reflect the political-administrative reality.